The San Francisco 49ers' rushing attack presents a big test for the Seattle Seahawks and their struggling defense.

Analyzing Thursday’s San Francisco 49ers at Seattle Seahawks odds and lines, with expert NFL picks and predictions.

The NFL's Week 6 will kick off with a "Thursday Night Football" matchup between two teams coming off head-scratching losses: ...

New York Giants linebacker Isaiah Simmons, who came up with a clutch blocked field goal in the team’s 29-20 Week 5 win ...

The New York Giants will be without one of their most important defenders, who is now "week-to-week" after undergoing wrist ...

The San Francisco 49ers will face off against the Seattle Seahawks in Week 6 of the NFL season on Thursday. This prediction ...

Samuel has accumulated 19.2 fantasy points (6.4 per game) during his past three games. He has 179 yards receiving, on 12 ...

In Week 6, wideout Jauan Jennings and the San Francisco 49ers' aerial attack will square off against the Seattle Seahawks and ...

Cincinnati Bengals head coach Zac Taylor addresses the media as his team prepares to play the New York Giants Sunday night at ...

Tim Patrick has played more than every Detroit Lions WR but Amon-Ra St. Brown and Jameson Williams since entering the ...

Malik Nabers is trending toward a return. Nabers, who missed last week's game due to a concussion, was expected to work with ...

Mike Macdonald shut down the San Francisco 49ers last season, and now looks to do the same with the Seattle Seahawks.