But Petzing doesn’t foresee a philosophical change to his offense. Kelvin Beachum is the right tackle since Williams’ injury, and Trystan Colon, who can play multiple offensive line spots, took over for Hernandez and played 20 snaps Sunday.

During his second NFL season, former Stanford wide receiver Michael Wilson has taken somewhat of a supporting role on the Arizona Cardinals, with the team draft

For two frustrating weeks, the Arizona Cardinals could not unlock the high-flying offense that had been promised. Against the Lions, they couldn’t run the ball. Against the Commanders, they couldn’t protect Kyler Murray. Both times, they became predictable and flat in disappointing losses.

The game against the Arizona Cardinals marked the second time this season that San Francisco (2-3) blew a double-digit lead in the fourth quarter to a division rival, having done it in Week 3 against the Los Angeles Rams.

Here is the NFL's list of everything you need to know when the San Francisco 49ers play the Arizona Cardinals in Week 5 of the 2024 NFL season.

Packers coach Matt LaFleur sees Kyler Murray as a dangerous off-schedule quarterback, so expect more contain rushes on Sunday.