The San Francisco 49ers are 3-3 on the season and, more importantly, in first place in the NFC West after a 36-24 win over ...

Quarterback Brock Purdy threw for 255 yards and three touchdowns en route to leading the San Francisco 49ers to a 36-24 road ...

Deebo Samuel had a 76-yard catch-and-run TD and finished with three catches for 102 yards for the defending NFC champions ...

At 2-3 overall and 0-2 in the NFC West division, a loss to the Seahawks wouldn't have buried the 49ers' season but it would ...

Lynch responded not with a specific position that needed bolstering but with a more abstract concept: The 49ers needed ...

Our best Same Game Parlay for 49ers vs. Seahawks features 49ers RB Jordan Mason, who could have a big night against Seattle's ...

A poor performance by Seahawks quarterback Geno Smith and the team's defense resulted in a 36-24 loss to the rival San Francisco 49ers in primetime on Thursday.

What channel is Thursday Night Football on? How to watch NFL Week 6 game between San Francisco 49ers, Seattle Seahawks on TV, ...

Brock Purdy threw for 255 yards and three touchdowns, and the San Francisco 49ers never trailed in a 36-24 victory over the ...

Kittle scored again and the 49ers led 29-17. The Seahawks got a touchdown back and trailed 29-24 with less than two minutes ...

Purdy threw for 255 yards and three touchdowns, and the Niners never trailed in a 36-24 victory over the Seattle Seahawks on ...

San Francisco spent the week answering questions about a slow start to the season before sending its strongest message to ...